Back to Biology: New Insights on Inheritance in Myeloproliferative Disorders
نویسندگان
چکیده
منابع مشابه
New insights into the pathogenesis and treatment of chronic myeloproliferative disorders.
PURPOSE OF REVIEW The classic BCR-ABL negative myeloproliferative disorders are at a crossroads of rapidly evolving pathogenetic understanding, leading to changes in diagnostic criteria and potentially targeted therapy. This review focuses on the implications of these changes relative to current standards. RECENT FINDINGS The V617F activating mutation of Janus kinase 2, and associated paralle...
متن کاملMyeloproliferative Disorders BCR-ABL1—Negative Myeloproliferative Neoplasms: A Review of Molecular Biology, Diagnosis, and Treatment
In 2008, the World Health Organization expanded the classification of myeloproliferative disorders based on increasing amounts of molecular and cytogenetic data. Myeloproliferative neoplasms (MPN) that do not contain the BCR-ABL1 mutation include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). JAK2V617F is the best characterized mutation in BCR-ABL1–nega...
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Myeloproliferative disorders (MPDs) constitute a group of hematopoietic malignancies that feature enhanced proliferation and survival of one or more myeloid lineage cells. William Dameshek is credited for introducing the term "MPDs" in 1951 when he used it to group chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) under one cl...
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Myeloproliferative Neoplasm (MPN) are a clonal disorder in hematopoietic stem cells (HSC). MPN is categorized to 8 subclasses, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocytopenia (ET), primary myelofibrosis (PMF), systematic mastositosis (SM), chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia (CNL), and unclassified myelofibrosis disorde...
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random monoallelic expression. Thus, the hypothesis of non-Mendelian inheritance remains valid, and the search for other mechanisms ensues. They do not exclude a complex situation in which both Mendelian and non-Mendelian mechanisms are at play. In the clinical part of this special issue, thyroid disorders associated with well-known genetic syndromes are carefully analyzed and reviewed. First, ...
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ژورنال
عنوان ژورنال: Current Hematologic Malignancy Reports
سال: 2014
ISSN: 1558-8211,1558-822X
DOI: 10.1007/s11899-014-0232-3